The National Centre for Research and Development



Small Grant Scheme; Level: PhD; Discipline: biocybernetics and biomedical engineering; ID: 209821



Project title: Mimicking natural endothelium - bioactive advanced materials for blood-contacting devices


Acronym: CardioMat


Project Promoter: Warsaw University of Technology/Faculty of Chemical and Process Engineering


Project cost (EUR): 90 827


Grant amount (EUR): 90 827

Duration: 12 months






Project summary:

Human life elongation and population aging increases demands for implant materials. Heart prostheses, vascular grafts, heart valves and coronary stents are used to treat the greatest killer of Western societies - cardiovascular diseases. Unfortunately, despite many years of intensive research materials used to fabricate synthetic implants still cause strong activation of platelets leading to formation of clots in the bloodstream, which, in turn, can have fatal consequences for the patient. Under physiological conditions the process of blood clotting is controlled by endothelial cells. These cells constantly and actively prevent thrombosis by releasing a number of substances. Synthetic materials are not able to release certain substances due to limited capacity. Thus, the most promising strategy to fabricate non-thrombogenic materials is covering the implant surface with a layer of endothelial cells. This approach seems to be the most close to ideal, leading to hybrid implants - artificial devices coated with a layer of living cells permanently connected to the implant and actively prevent platelet activation and transplant rejection. Endothelial cells can be applied onto the synthetic implant before the procedure or can be recruited from the bloodstream and the surrounding areas. Unfortunately, in order to create such bioactive surface we need to better understand the interactions between endothelial cells and artificial surfaces. For this purpose, within the presented project a number of materials with targeted surface modifications will be produced. Next, the behavior of endothelial cells in contact with fabricated materials will be investigated. Such studies are important for understanding the mechanisms of interactions of human body with synthetic implants.

The National Centre for Research and Development
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